In our study published in PLOS One, we characterized the postnatal histological development of five major internal organs—liver, kidney, spleen, lung, and heart—in infant common marmosets. Using H&E, Ki67 immunohistochemistry, Alcian blue–PAS, and Sirius red staining, we compared tissue architecture and maturation between infant and adult animals.

We found that infant marmosets exhibited distinct developmental features across multiple organs, including extramedullary hematopoiesis and immature hepatic architecture in the liver, active nephrogenesis in the kidney, poorly developed white pulp in the spleen, thick interalveolar septa and immature alveolar structures in the lung, and loosely organized cardiomyocytes with immature myocardial and valvular structures in the heart. These findings were accompanied by higher Ki67-positive cell populations in infant tissues, reflecting active postnatal growth and remodeling.

Overall, this study provides a histological reference for normal postnatal organ development in common marmosets and highlights the importance of distinguishing developmental features from pathological changes when evaluating tissues from young animals. These findings may support the interpretation of developmental pathology and the use of infant marmosets in biomedical and preclinical research.

Standardizing Necropsy and Tissue Processing for Histopathological Analysis in Common Marmosets

In our study published in STAR Protocols, we established a standardized protocol for necropsy and tissue processing in common marmosets (Callithrix jacchus), an increasingly important non-human primate model in biomedical research. The protocol provides step-by-step guidance for external examination, blood collection, systematic organ removal, fixation, tissue trimming, processing, and embedding for histopathological evaluation.

We also provide detailed anatomical landmarks, tissue orientation guidelines, and standardized sampling procedures to improve consistency and reproducibility across studies. By minimizing postmortem artifacts and variability in tissue collection and preparation, this protocol enables researchers to obtain high-quality histological specimens and provides a practical reference for preclinical, infectious disease, neurodegenerative, and developmental or reproductive toxicity studies using common marmosets.

Mapping Nasal Epithelial Zonation and Turbinate Development in Infant Common Marmosets

In our study published in Scientific Reports, we characterized the postnatal development of the nasal cavity in common marmosets (Callithrix jacchus). Using high-resolution micro-CT and histological analyses, we compared nasal turbinate morphology and epithelial distribution across neonatal, infant, and adult stages.

We found that young marmosets had relatively simple and immature maxilloturbinate and ethmoturbinate structures compared with adults, while the spatial zonation of squamous, transitional, respiratory, and olfactory epithelia was already largely established early in life. Increased epithelial proliferation and lower goblet cell abundance in young animals further suggested continued structural and functional maturation after birth. These findings provide a useful anatomical and histological reference for respiratory, olfactory, and preclinical studies using common marmosets.

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